Evolutionary screening of precision oncology biomarkers and its applications in prognostic model construction.

ABSTRACT: Biomarker screening is critical for precision oncology. However, one of the main challenges in precision oncology is that the screened biomarkers often fail to achieve the expected clinical effects and are rarely approved by regulatory authorities. Considering the close association between cancer pathogenesis and the evolutionary events of organisms, we first explored the evolutionary feature underlying clinically approved biomarkers, and two evolutionary features of approved biomarkers (Ohnologs and specific evolutionary stages of genes) were identified. Subsequently, we utilized evolutionary features for screening potential prognostic biomarkers in four common cancers: head and neck squamous cell carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, and lung squamous cell carci

SUBMITTER: Zhang ZW 

PROVIDER: S-EPMC11126775 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature