Comparison of HPV-positive triage strategies combining extended genotyping with cytology or p16/ki67 dual staining in the Italian NTCC2 study.

ABSTRACT:

Background

Each high-risk HPV genotype has different oncogenic potential, and the risk of CIN3+ varies according to genotype. We evaluated the performance of different strategies of HPV-positivity triage combining cytology, p16/ki67 dual staining (DS), and extended genotyping.

Methods

Samples from 3180 consecutive women from the NTCC2 study (NCT01837693) positive for HPV DNA at primary screening, were retrospectively analyzed by the BD Onclarity HPV Assay, which allows extended genotyping. Genotypes were divided into three groups based on the risk of CIN3+. HPV DNA-positive women were followed up for 24 months or to clearance.

Findings

Combining the three groups of genotypes with cytology or DS results we identify a group of women who need immediate colposcopy (PPV fo

SUBMITTER: Benevolo M 

PROVIDER: S-EPMC11126882 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature