Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia.

ABSTRACT:

Purpose of review

Over the last decade, evidence suggests that a combination of behavioral and neuroimaging findings can help illuminate changes in functional dysconnectivity in schizophrenia. We review the recent connectivity literature considering several vital models, considering connectivity findings, and relationships with clinical symptoms. We reviewed resting state fMRI studies from 2017 to 2023. We summarized the role of two sets of brain networks (cerebello-thalamo-cortical (CTCC) and the triple network set) across three hypothesized models of schizophrenia etiology (neurodevelopmental, vulnerability-stress, and neurotransmitter hypotheses).

Recent findings

The neurotransmitter and neurodevelopmental models best explained CTCC-subcortical dysfunction, which was cons

SUBMITTER: Harikumar A 

PROVIDER: S-EPMC11126894 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature