The physical and evolutionary energy landscapes of devolved protein sequences corresponding to pseudogenes.

ABSTRACT: Protein evolution is guided by structural, functional, and dynamical constraints ensuring organismal viability. Pseudogenes are genomic sequences identified in many eukaryotes that lack translational activity due to sequence degradation and thus over time have undergone "devolution." Previously pseudogenized genes sometimes regain their protein-coding function, suggesting they may still encode robust folding energy landscapes despite multiple mutations. We study both the physical folding landscapes of protein sequences corresponding to human pseudogenes using the Associative Memory, Water Mediated, Structure and Energy Model, and the evolutionary energy landscapes obtained using direct coupling analysis (DCA) on their parent protein families. We found that generally mutations that have occ

SUBMITTER: Jaafari H 

PROVIDER: S-EPMC11127006 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature