PM_2.5 exposure contributes to anxiety and depression-like behaviors via phenyl-containing compounds interfering with dopamine receptor.

ABSTRACT: As a global problem, fine particulate matter (PM_2.5) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, the most important question is to clarify whether and how PM_2.5 causally contributes to these mental disorders and which components are the most dangerous for crucial mitigation in a particular place. In the present study, we chronically subjected male mice to a real-world PM_2.5 exposure system throughout the winter heating period in a coal combustion area and revealed that PM_2.5 caused anxiety and depression-like behaviors in adults such as restricted activity, diminished exploratory interest, enhanced repetitive stereotypy, and elevated acquired immo

SUBMITTER: Ji S 

PROVIDER: S-EPMC11127009 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature