Activity-driven chromatin organization during interphase: Compaction, segregation, and entanglement suppression.

ABSTRACT: In mammalian cells, the cohesin protein complex is believed to translocate along chromatin during interphase to form dynamic loops through a process called active loop extrusion. Chromosome conformation capture and imaging experiments have suggested that chromatin adopts a compact structure with limited interpenetration between chromosomes and between chromosomal sections. We developed a theory demonstrating that active loop extrusion causes the apparent fractal dimension of chromatin to cross-over between two and four at contour lengths on the order of 30 kilo-base pairs. The anomalously high fractal dimension [Formula: see text] is due to the inability of extruded loops to fully relax during active extrusion. Compaction on longer contour length scales extends within topologically associa

SUBMITTER: Chan B 

PROVIDER: S-EPMC11127048 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature