The effect of dental material type and masticatory forces on periodontitis-derived subgingival microbiomes.

ABSTRACT: Restorative dental materials can frequently extend below the gingival margin, serving as a potential haven for microbial colonization, and altering the local oral microbiome to ignite infection. However, the contribution of dental materials on driving changes of the composition of the subgingival microbiome is under-investigated. This study evaluated the microbiome-modulating properties of three biomaterials, namely resin dental composites (COM), antimicrobial piezoelectric composites (BTO), and hydroxyapatite (HA), using an optimized in vitro subgingival microbiome model derived from patients with periodontal disease. Dental materials were subjected to static or cyclic loading (mastication forces) during biofilm growth. Microbiome composition was assessed by 16S rRNA gene sequencin

SUBMITTER: Montoya C 

PROVIDER: S-EPMC11127099 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature