Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening.

ABSTRACT: Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the precision of disease modeling and offer more dependable and comprehensive drug screening. High-throughput microphysiological systems that support optional, parallel testing of multiple drugs have promising applications in personalized medical treatment and drug research. However, establishing such a system is highly challenging and requires a multidisciplinary approach. This study introduces a dynamic Microphysiological System Chip Platform (MSCP) with multiple functional microstructures that encompass the mentioned advantages. We developed a hi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11127178 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature