Safety and Feasibility of Stereotactic Radiosurgery for Patients with 15 or more Brain Metastases.

ABSTRACT:

Background

Current standard of care treatment for patients with ≥15 brain metastases (BM) is whole brain radiation therapy (WBRT), despite poor neurocognitive outcomes. We analyzed our institutional experience of treating these patients with stereotactic radiosurgery (SRS), with the aim of evaluating safety, cognitive outcomes, and survival metrics.

Methods

Patients who received SRS for ≥15 BMs in 1 to 5 fractions from 2014 to 2022 were included. Cognitive outcomes were objectively evaluated using serial Patient-Reported Outcome Measurement Information System (PROMIS) scores. The Kaplan-Meier method was used for survival analysis and log-rank test for intergroup comparisons.

Results

Overall, 118 patients underwent 124 courses of LINAC-based SRS. The median number of l

SUBMITTER: Upadhyay R 

PROVIDER: S-EPMC11127210 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature