The CD6 interactome orchestrates ligand-independent T cell inhibitory signaling.

ABSTRACT:

Background

T-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular signalosome, it is distinguished from typical scaffolds like LAT or PAG by possessing a substantial ectodomain that binds CD166, a well-characterized ligand expressed on most antigen-presenting cells (APC), through the third domain (d3) of the extracellular region. Although the intact form of CD6 is the most abundant in T cells, an isoform lacking d3 (CD6∆d3) is transiently expressed on activated T cells. Still, the precise character of the signaling transduced by CD6, whether costimulatory or inhibitory, and the influence of its ectodomain on these activities are unclear.

Methods

We expressed CD6 variants with extracellular d

SUBMITTER: Santos RF 

PROVIDER: S-EPMC11127300 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature