Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I <i>TTR</i> carriers in the general population.

ABSTRACT:

Background

Hereditary transthyretin cardiac amyloidosis (ATTRv-CA) has a long latency phase before clinical onset, creating a need to identify subclinical disease. We hypothesized circulating transthyretin (TTR) and retinol binding protein 4 (RBP4) levels would be associated with TTR carrier status and correlated with possible evidence of subclinical ATTRv-CA.

Methods

TTR and RBP4 were measured in blood samples from V122I TTR carriers and age-, sex- and race-matched non-carrier controls (1:2 matching) among Dallas Heart Study participants (phases 1 (DHS-1) and 2 (DHS-2)). Multivariable linear regression models determined factors associated with TTR and RBP4.

Results

There were 40 V122I TTR carriers in DHS-1 and 54 V122I TTR carriers in DHS-

SUBMITTER: Hendren NS 

PROVIDER: S-EPMC11127723 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature