An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys.

ABSTRACT:

Background

High-precision neurosurgical targeting in nonhuman primates (NHPs) often requires presurgical anatomical mapping with noninvasive neuroimaging techniques (MRI, CT, PET), allowing for translation of individual anatomical coordinates to surgical stereotaxic apparatus. Given the varied tissue contrasts that these imaging techniques produce, precise alignment of imaging-based coordinates to surgical apparatus can be cumbersome. MRI-compatible stereotaxis with radiopaque fiducial markers offer a straight-forward and reliable solution, but existing commercial options do not fit in conformal head coils that maximize imaging quality.

New method

We developed a compact MRI-compatible stereotaxis suitable for a variety of NHP species (Macaca mulatta, Macaca fascicularis, and

SUBMITTER: Liang L 

PROVIDER: S-EPMC11127775 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature