Neuronal autosis is Na⁺/K⁺-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death.

ABSTRACT: Macroautophagy (hereafter called autophagy) is an essential physiological process of degradation of organelles and long-lived proteins. The discovery of autosis, a Na⁺/K⁺-ATPase (ATP1)-dependent type of autophagic cell death with specific morphological and biochemical features, has strongly contributed to the acceptance of a pro-death role of autophagy. However, the occurrence and relevance of autosis in neurons has never been clearly investigated, whereas we previously provided evidence that autophagy mechanisms could be involved in neuronal death in different in vitro and in vivo rodent models of hypoxia-ischemia (HI) and that morphological features of autosis were observed in dying neurons following rat perinatal cerebral HI. In the present study, we demonstrated t

SUBMITTER: Depierre P 

PROVIDER: S-EPMC11127954 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature