Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.

ABSTRACT: About half of the neurons in the parabrachial nucleus (PB) that are activated by CO₂ are located in the external lateral (el) subnucleus, express calcitonin gene-related peptide (CGRP), and cause forebrain arousal. We report here, in male mice, that most of the remaining CO₂-responsive neurons in the adjacent central lateral (PBcl) and Kölliker-Fuse (KF) PB subnuclei express the transcription factor FoxP2 and many of these neurons project to respiratory sites in the medulla. PBcl^FoxP2 neurons show increased intracellular calcium during wakefulness and REM sleep and in response to elevated CO₂ during NREM sleep. Photo-activation of the PBcl^FoxP2 neurons increases respiration, whereas either photo-inhibition of PBcl^FoxP2 or ge

SUBMITTER: Kaur S 

PROVIDER: S-EPMC11128025 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature