Integrated multi-omics approach reveals novel associations in the rapeseed diet-microbiota-host axis in pigs.

ABSTRACT: Diet-mediated host-microbiota interplay is a key factor in optimizing the gut function and overall health of the host. Gaining insight into the biological mechanisms behind this relationship is fundamental to finding sustainable, environment-friendly feed solutions in livestock production systems. Here, we apply a multi-omics integration approach to elucidate sustainable diet-associated host-gut microbiota interactions in pigs and we demonstrate novel and biologically relevant host-microbe associations in the gut, driven by a rapeseed meal-based feed (RSF). Interestingly, RSF-diet promoted the abundance of segmented filamentous bacteria Candidatus Arthromitus that was associated with the maintenance of mucosal immunity in the ileum of pigs. In the colon, RSF diet affected host mRNA

SUBMITTER: Onarman Umu OC 

PROVIDER: S-EPMC11128262 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature