A comprehensive benchmarking of machine learning algorithms and dimensionality reduction methods for drug sensitivity prediction.

ABSTRACT: A major challenge of precision oncology is the identification and prioritization of suitable treatment options based on molecular biomarkers of the considered tumor. In pursuit of this goal, large cancer cell line panels have successfully been studied to elucidate the relationship between cellular features and treatment response. Due to the high dimensionality of these datasets, machine learning (ML) is commonly used for their analysis. However, choosing a suitable algorithm and set of input features can be challenging. We performed a comprehensive benchmarking of ML methods and dimension reduction (DR) techniques for predicting drug response metrics. Using the Genomics of Drug Sensitivity in Cancer cell line panel, we trained random forests, neural networks, boosting trees and elastic net

SUBMITTER: Eckhart L 

PROVIDER: S-EPMC11128483 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature