Causal role of immune cells in Hashimoto's thyroiditis: Mendelian randomization study.

ABSTRACT:

Objectives

Hashimoto's thyroiditis (HT) is a common autoimmune disease whose etiology involves a complex interplay between genetics and environment. Previous studies have demonstrated an association between immune cells and HT. However, the casual relationship was not clear. We aimed to explore the causal associations between signatures of immune cells and HT.

Methods

In this study, bidirectional two-sample Mendelian randomization (MR) analysis was conducted to investigate the potential causal relationship between 731 immune cell signatures and HT by using genome-wide association study (GWAS) data. Heterogeneity and horizontal pleiotropy were detected through extensive sensitivity analyses.

Results

The increased levels of six immune phenotypes were observed to be caus

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11128540 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature