Gut microbiota, inflammatory proteins and COVID-19: a Mendelian randomisation study.

ABSTRACT:

Background

The human gut microbiota has been identified as a potentially important factor influencing the development of COVID-19. It is believed that the disease primarily affects the organism through inflammatory pathways. With the aim of improving early diagnosis and targeted therapy, it is crucial to identify the specific gut microbiota associated with COVID-19 and to gain a deeper understanding of the underlying processes. The present study sought to investigate the potential causal relationship between the gut microbiota and COVID-19, and to determine the extent to which inflammatory proteins act as mediators in this relationship.

Methods

Bidirectional mendelian randomization (MR) and Two-step mediated MR analyses were applied to examine causative associations among 19

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11128586 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature