Valine induces inflammation and enhanced adipogenesis in lean mice by multi-omics analysis.

ABSTRACT:

Introduction

The branched-chain amino acids (BCAAs) are essential to mammalian growth and development but aberrantly elevated in obesity and diabetes. Each BCAA has an independent and specific physio-biochemical effect on the host. However, the exact molecular mechanism of the detrimental effect of valine on metabolic health remains largely unknown.

Methods and results

This study showed that for lean mice treated with valine, the hepatic lipid metabolism and adipogenesis were enhanced, and the villus height and crypt depth of the ileum were significantly increased. Transcriptome profiling on white and brown adipose tissues revealed that valine disturbed multiple signaling pathways (e.g., inflammation and fatty acid metabolism). Integrative cecal metagenome and metabolome ana

SUBMITTER: Zheng HY 

PROVIDER: S-EPMC11128663 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature