Determinants of radiographic progression in early psoriatic arthritis: insights from a real-world cohort.

ABSTRACT:

Objective

Persistent articular inflammation in psoriatic arthritis (PsA) is associated with radiographic damage. Despite advances in diagnosis and therapy, radiographic structural damage remains prevalent in PsA. To elucidate this topic, we studied which baseline clinical characteristics determine radiographic progression.

Methods

For this analysis, data were used from DEPAR (Dutch South West Psoriatic Arthritis) Study, a real-world cohort of patients with newly diagnosed PsA. Radiographic changes were assessed using the modified Total Sharp/van der Heijde Score (mTSS) for PsA. Univariable-multivariable mixed-effects negative binomial regression analysis was applied to define baseline predictors for radiographic progression over time.

Results

The study included 476 pa

SUBMITTER: Koc GH 

PROVIDER: S-EPMC11129034 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature