Peripheral inflammatory response in people after acute ischaemic stroke and isolated spontaneous cervical artery dissection.

ABSTRACT: The systemic inflammatory response following acute ischaemic stroke remains incompletely understood. We characterised the circulating inflammatory profile in 173 acute ischaemic stroke patients by measuring 65 cytokines and chemokines in plasma. Participants were grouped based on their inflammatory response, determined by high-sensitivity C-reactive protein levels in the acute phase. We compared stroke patients' profiles with 42 people experiencing spontaneous cervical artery dissection without stroke. Furthermore, variations in cytokine levels among stroke aetiologies were analysed. Follow-up samples were collected in a subgroup of ischaemic stroke patients at three and twelve months. Ischaemic stroke patients had elevated plasma levels of HGF and SDF-1α, and lower IL-4 levels, compared t

SUBMITTER: Bauer A 

PROVIDER: S-EPMC11130263 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature