Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.

ABSTRACT: Jamaican fruit bats (Artibeus jamaicensis) naturally harbor a wide range of viruses of human relevance. These infections are typically mild in bats, suggesting unique features of their immune system. To better understand the immune response to viral infections in bats, we infected male Jamaican fruit bats with the bat-derived influenza A virus (IAV) H18N11. Using comparative single-cell RNA sequencing, we generated single-cell atlases of the Jamaican fruit bat intestine and mesentery. Gene expression profiling showed that H18N11 infection resulted in a moderate induction of interferon-stimulated genes and transcriptional activation of immune cells. H18N11 infection was predominant in various leukocytes, including macrophages, B cells, and NK/T cells. Confirming these findings, human leukoc

SUBMITTER: Kessler S 

PROVIDER: S-EPMC11130286 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature