Novel insight into the genetic signatures of altitude adaptation related body composition in Tibetans.

ABSTRACT:

Background

The Tibetan population residing in high-altitude (HA) regions has adapted to extreme hypoxic environments. However, there is limited understanding of the genetic basis of body compositions in Tibetan population adapted to HA.

Methods

We performed a genome-wide association study (GWAS) to identify genetic variants associated with HA and HA-related body composition traits. A total of 755,731 single nucleotide polymorphisms (SNPs) were genotyped using the precision medicine diversity array from 996 Tibetan college students. T-tests and Pearson correlation analysis were used to estimate the association between body compositions and altitude. The mixed linear regression identified the SNPs significantly associated with HA and HA-related body compositions. LASSO regress

SUBMITTER: Li X 

PROVIDER: S-EPMC11130355 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature