Identification of the changes in the platelet proteomic profile of elderly individuals.

ABSTRACT:

Background

Platelet hyperreactivity is a risk factor for thrombosis in elderly patients with cardiovascular diseases. However, the mechanism of platelet hyperactivation has not been elucidated. This study aims to investigate alterations in the proteomes of platelets and their correlation with platelet hyperreactivity among elderly individuals.

Methods

This study included 10 young (28.1 ± 1.9 years), 10 middle-aged (60.4 ± 2.2 years), and 10 old (74.2 ± 3.0 years) subjects. Washed platelets were used in the present study. Platelet samples were analysed by using data-independent acquisition (DIA) quantitative mass spectrometry (MS).

Results

The results showed that the platelet proteomic profile exhibited high similarity between the young and middle-aged groups. However,

SUBMITTER: Chen HL 

PROVIDER: S-EPMC11130443 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature