Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.

ABSTRACT:

Background

Higher 25-hydroxyvitamin D (25(OH)D) concentrations in serum has a positive association with pulmonary function. Investigating genome-wide interactions with 25(OH)D may reveal new biological insights into pulmonary function.

Objectives

We aimed to identify novel genetic variants associated with pulmonary function by accounting for 25(OH)D interactions.

Methods

We included 211,264 participants from the observational United Kingdom Biobank study with pulmonary function tests (PFTs), genome-wide genotypes, and 25(OH)D concentrations from 4 ancestral backgrounds-European, African, East Asian, and South Asian. Among PFTs, we focused on forced expiratory volume in the first second (FEV₁) and forced vital capacity (FVC) because both were previously asso

SUBMITTER: Seo J 

PROVIDER: S-EPMC11130669 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature