Biomarker-assessed total energy intake and its cohort study association with all-cause mortality in postmenopausal females.

ABSTRACT:

Background

The association of total energy intake (EI) with all-cause mortality is uncertain as are the dependencies of this association on age and weight change history.

Objectives

To identify an EI biomarker suitable for use in epidemiologic association studies and to study EI associations with total mortality in a Women's Health Initiative (WHI) cohort of postmenopausal United States females (1993-present).

Methods

EI biomarkers were developed based on doubly labeled water (DLW) total energy expenditure (TEE) and weight variation during the 2-wk DLW protocol period using the energy balance method in an embedded feeding study (n = 153). This along with 2 earlier WHI nutrition biomarker studies having TEE assessments (n = 1131 total), with 14.6 y (median) follow-up,

SUBMITTER: Prentice RL 

PROVIDER: S-EPMC11130702 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature