Changing selection on amino acid substitutions in Gag protein between major HIV-1 subtypes.

ABSTRACT: Amino acid preferences at a protein site depend on the role of this site in protein function and structure as well as on external constraints. All these factors can change in the course of evolution, making amino acid propensities of a site time-dependent. When viral subtypes divergently evolve in different host subpopulations, such changes may depend on genetic, medical, and sociocultural differences between these subpopulations. Here, using our previously developed phylogenetic approach, we describe sixty-nine amino acid sites of the Gag protein of human immunodeficiency virus type 1 (HIV-1) where amino acids have different impact on viral fitness in six major subtypes of the type M. These changes in preferences trigger adaptive evolution; indeed, 32 (46 per cent) of these sites experien

SUBMITTER: Klink GV 

PROVIDER: S-EPMC11131029 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature