Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians.

ABSTRACT:

Background

Obesity is a global public health concern linked to chronic diseases such as cardiovascular disease and type 2 diabetes (T2D). Emerging evidence suggests that epigenetic modifications, particularly DNA methylation, may contribute to obesity. However, the molecular mechanism underlying the longitudinal change of BMI has not been well-explored, especially in East Asian populations.

Methods

This study performed a longitudinal epigenome-wide association analysis of DNA methylation to uncover novel loci associated with BMI change in 533 individuals across two Chinese cohorts with repeated DNA methylation and BMI measurements over four years.

Results

We identified three novel CpG sites (cg14671384, cg25540824, and cg10848724) significantly associated with BMI cha

SUBMITTER: Li W 

PROVIDER: S-EPMC11131215 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature