Integrative multiomics analysis identifies molecular subtypes and potential targets of hepatocellular carcinoma.

ABSTRACT:

Background

The liver is anatomically divided into eight segments based on the distribution of Glisson's triad. However, the molecular mechanisms underlying each segment and its association with hepatocellular carcinoma (HCC) heterogeneity are not well understood. In this study, our objective is to conduct a comprehensive multiomics profiling of the segmentation atlas in order to investigate potential subtypes and therapeutic approaches for HCC.

Methods

A high throughput liquid chromatography-tandem mass spectrometer strategy was employed to comprehensively analyse proteome, lipidome and metabolome data, with a focus on segment-resolved multiomics profiling. To classify HCC subtypes, the obtained data with normal reference profiling were integrated. Additionally, potential th

SUBMITTER: Yang S 

PROVIDER: S-EPMC11131356 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature