Differential transcriptional profiles of vagal sensory neurons in female and male mice.

ABSTRACT:

Introduction

Differences in metabolic homeostasis, diabetes, and obesity between males and females are evident in rodents and humans. Vagal sensory neurons in the vagus nerve ganglia innervate a variety of visceral organs and use specialized nerve endings to sense interoceptive signals. This visceral organ-brain axis plays a role in relaying interoceptive signals to higher brain centers, as well as in regulating the vago-vagal reflex. I hypothesized that molecularly distinct populations of vagal sensory neurons would play a role in causing differences in metabolic homeostasis between the sexes.

Methods

SnRNA-Seq was conducted on dissociated cells from the vagus nerve ganglia using the 10X Genomics Chromium platform.

Results

Single-nucleus RNA sequencing analysis of va

SUBMITTER: Jo YH 

PROVIDER: S-EPMC11131592 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature