The identification of a N⁶-methyladenosin-modifed immune pattern to predict immunotherapy response and survival in urothelial carcinoma.

ABSTRACT:

Background

Dysregulation of the immune system and N⁶-methyladenosine (m6A) contribute to immune therapy resistance and cancer progression in urothelial carcinoma (UC). This study aims to identify immune-related molecules, that are m6A-modified, and that are associated with tumor progression, poor prognosis, and immunotherapy response.

Methods

We identified prognostic immune genes (PIGs) using Cox analysis and random survival forest variable hunting algorithm (RSF-VH) on immune genes retrieved from the Immunology Database and Analysis Portal database (ImmPort). The RM2Target database and MeRIP-seq analysis, combined with a hypergeometric test, assessed m6A methylation in these PIGs. We analyzed the correlation between the immune pattern and prognosis, as well as th

SUBMITTER: Mao X 

PROVIDER: S-EPMC11131986 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature