Bioinformatics analysis and validation of mesenchymal stem cells related gene MT1G in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is a primary malignant bone tumor arising from mesenchymal cells. The standard clinical treatment for OS involves extensive tumor resection combined with neoadjuvant chemotherapy or radiotherapy. OS's invasiveness, lung metastasis, and drug resistance contribute to a low cure rate and poor prognosis with this treatment. Metallothionein 1G (MT1G), observed in various cancers, may serve as a potential therapeutic target for OS.

Methods

OS samples in GSE33382 and TARGET datasets were selected as the test cohorts. As the external validation cohort, 13 OS tissues and 13 adjacent cancerous tissues from The Second Affiliated Hospital of Nanchang University were collected. Patients with OS were divided into high and low MT1G mRNA-expression groups; diffe

SUBMITTER: Zheng S 

PROVIDER: S-EPMC11131992 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature