Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses.

ABSTRACT: Macrophages regulate essential aspects of innate immunity against pathogens. In response to microbial components, macrophages activate primary and secondary inflammatory gene programs crucial for host defense. The liver X receptors (LXRα, LXRβ) are ligand-dependent nuclear receptors that direct gene expression important for cholesterol metabolism and inflammation, but little is known about the individual roles of LXRα and LXRβ in antimicrobial responses. Here, the results demonstrate that induction of LXRα transcription by prolonged exposure to lipopolysaccharide (LPS) supports inflammatory gene expression in macrophages. LXRα transcription is induced by NF-κB and type-I interferon downstream of TLR4 activation. Moreover, LPS triggers a reprogramming of the LXRα cistrome that promotes cyto

SUBMITTER: Vladimir de la Rosa J 

PROVIDER: S-EPMC11132038 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature