Identification of a pyroptosis-related prognosis gene signature and its relationship with an immune microenvironment in gliomas.

ABSTRACT:

Background

Glioma is the most common type of primary brain cancer, and the prognosis of most patients with glioma is poor. Pyroptosis is a newly discovered inflammatory programmed cell death. However, the expression of pyroptosis-related genes (PRGs) in glioma and its correlation with prognosis are unclear.

Methods

27 pyroptosis genes differentially expressed between glioma and adjacent normal tissues were identified. All glioma cases could be stratified into 2 subtypes based on these differentially expressed PRGs. The prognostic value of each PRG was evaluated to construct a prognostic model.

Results

A novel 16-gene signature was constructed by using the least absolute shrinkage and selection operator Cox regression method. Then, patients with glioma were divided int

SUBMITTER: Xiao S 

PROVIDER: S-EPMC11132325 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature