Plasmodium falciparum AMA1 and CSP antigen diversity in parasite isolates from southern Ghana.

ABSTRACT:

Introduction

Diversity in malarial antigens is an immune evasion mechanism that gives malaria parasites an edge over the host. Immune responses against one variant of a polymorphic antigen are usually not fully effective against other variants due to altered epitopes. This study aimed to evaluate diversity in the Plasmodium falciparum antigens apical membrane antigen 1 (PfAMA1) and circumsporozoite protein (PfCSP) from circulating parasites in a malaria-endemic community in southern Ghana and to determine the effects of polymorphisms on antibody response specificity.

Methods

The study involved 300 subjects, whose P. falciparum infection status was determined by microscopy and PCR. Diversity within the two antigens was evaluated by msp2 gene typing and molecular gene s

SUBMITTER: Kusi KA 

PROVIDER: S-EPMC11132687 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature