Oxidative potential of the inhalation bioaccessible fraction of PM₁₀ and bioaccessible concentrations of polycyclic aromatic hydrocarbons and metal(oid)s in PM₁₀.

ABSTRACT: Atmospheric particulate matter (PM) has been related to numerous adverse health effects in humans. Nowadays, it is believed that one of the possible mechanisms of toxicity could be the oxidative stress, which involves the development of reactive oxygen species (ROS). Different assays have been proposed to characterize oxidative stress, such as dithiothreitol (DTT) and ascorbic acid (AA) acellular assays (OP^DTT and OP^AA), as a metric more relevant than PM mass measurement for PM toxicity. This study evaluates the OP of the bioaccessible fraction of 65 PM₁₀ samples collected at an Atlantic Coastal European urban site using DTT and AA assays. A physiologically based extraction (PBET) using Gamble's solution (GS) as a simulated lung fluid (SLF) was used for the

SUBMITTER: Novo-Quiza N 

PROVIDER: S-EPMC11133103 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature