Exercise derived myokine irisin as mediator of cardiorespiratory, metabolic and thermal adjustments during central and peripheral chemoreflex activation.

ABSTRACT: Exercise elicits physiological adaptations, including hyperpnea. However, the mechanisms underlying exercise-induced hyperpnea remain unresolved. Skeletal muscle acts as a secretory organ, releasing irisin (IR) during exercise. Irisin can cross the blood-brain barrier, influencing muscle and tissue metabolism, as well as signaling in the central nervous system (CNS). We evaluated the effect of intracerebroventricular or intraperitoneal injection of IR in adult male rats on the cardiorespiratory and metabolic function during sleep-wake cycle under room air, hypercapnia and hypoxia. Central IR injection caused an inhibition on ventilation (V_E) during wakefulness under normoxia, while peripheral IR reduced V_E during sleep. Additionally, central IR exacerbates hypercapnic

SUBMITTER: Bernardes-Ribeiro M 

PROVIDER: S-EPMC11133352 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature