Temperature-dependent iron motion in extremophile rubredoxins - no need for 'corresponding states'.

ABSTRACT: Extremophile organisms are known that can metabolize at temperatures down to - 25 °C (psychrophiles) and up to 122 °C (hyperthermophiles). Understanding viability under extreme conditions is relevant for human health, biotechnological applications, and our search for life elsewhere in the universe. Information about the stability and dynamics of proteins under environmental extremes is an important factor in this regard. Here we compare the dynamics of small Fe-S proteins - rubredoxins - from psychrophilic and hyperthermophilic microorganisms, using three different nuclear techniques as well as molecular dynamics calculations to quantify motion at the Fe site. The theory of 'corresponding states' posits that homologous proteins from different extremophiles have comparable flexibilities at

SUBMITTER: Jenney FE 

PROVIDER: S-EPMC11133467 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature