Structural and functional alteration of the gut microbiota in elderly patients with hyperlipidemia.

ABSTRACT:

Objective

To investigate the structure, composition, and functions of the gut microbiota in elderly patients with hyperlipidemia.

Methods

Sixteen older patients diagnosed with hyperlipidemia (M group) and 10 healthy, age-matched normal volunteers (N group) were included. These groups were further subdivided by sex into the male normal (NM, n = 5), female normal (NF, n = 5), male hyperlipidemia (MM, n = 8), and female hyperlipidemia (MF, n = 8) subgroups. Stool samples were collected for high-throughput sequencing of 16S rRNA genes. Blood samples were collected for clinical biochemical index testing.

Results

Alpha- and beta-diversity analyses revealed that the structure and composition of the gut microbiota were significantly different between the M and N groups. The r

SUBMITTER: Xia M 

PROVIDER: S-EPMC11133514 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature