Gut microbiome alterations during gastric cancer: evidence assessment of case-control studies.

ABSTRACT:

Objectives

The study aims to systematically identify the alterations in gut microbiota that observed in gastric cancer through comprehensive assessment of case-control studies.

Methods

The systematic literature search of PubMed, Embase, Cochrane Library, and Web of Science was conducted to identify case-control studies that compared the microbiomes of individuals with and without gastric cancer. Quality of included studies was evaluated with the Newcastle-Ottawa Quality Assessment Scale (NOS). Meta-analyses utilized a random-effects model, and subgroup and sensitivity analyses were performed to assess study heterogeneity. All data analyses were performed using the "metan" package in Stata 17.0, and the results were described using log odds ratios (log ORs) with 95% confidenc

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11133546 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature