The causal relationship between vitiligo and autoimmune thyroid diseases: A bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Vitiligo is an acquired autoimmune depigmented disorder characterized by the presence of white and well-defined patches on the skin, mucous membrane, or both. It is associated with a significant disease burden and has a profoundly impacts patients' quality of life. Autoimmune thyroid diseases (AITDs) result from an autoimmune system dysregulation, leading to an erroneous immune attack on the thyroid gland. Previous observational and epidemiological studies have suggested the association between vitiligo and AITDs. However, the bidirectional cause-effect relationship between vitiligo and AITDs has not been formally assessed.

Method

Two-sample bidirectional Mendelian randomization (MR) analysis was conducted to explore potential causal relationships between genetica

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11133963 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature