Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank.

ABSTRACT:

Background

In 2020, the Lancet Commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified APOE e4/e4 genotype and family history of Alzheimer's disease strongly associated with dementia outcomes; however, it is unclear how robust these relationships are across dementia subtypes and analytic scenarios. Specification curve analysis (SCA) is a new tool to probe how plausible analytical scenarios influence outcomes.

Methods

We evaluated the heterogeneity of odds ratios for 12 risk factors reported from the Lancet 2020 report and two additional strong associated non-modifiable factors (APOE e4/e4 genotype and family history of Alzheimer's disease) with dementia outcomes across 450,707 UK Biobank participants using SCA with 5357 sp

SUBMITTER: Luo R 

PROVIDER: S-EPMC11134914 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature