Non-contact immunological signaling for highly-efficient regulation of the transcriptional map of human monocytes.

ABSTRACT: The different immune system cells communicate and coordinate a response using a complex and evolved language of cytokines and chemokines. These cellular interactions carry out multiple functions in distinct cell types with numerous developmental outcomes. Despite the plethora of different cytokines and their cognate receptors, there is a restricted number of signal transducers and activators to control immune responses. Herein, we report on a new class of immunomodulatory signaling molecules based on volatile molecules (VMs, namely, volatile organic compounds [VOCs]), by which they can affect and/or control immune cell behavior and transcriptomic profile without any physical contact with other cells. The study demonstrates the role of VMs by analyzing non-contact cell communication between

SUBMITTER: Hashoul D 

PROVIDER: S-EPMC11135151 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature