Wiring Between Close Nodes in Molecular Networks Evolves More Quickly Than Between Distant Nodes.

ABSTRACT: As species diverge, a wide range of evolutionary processes lead to changes in protein-protein interaction (PPI) networks and metabolic networks. The rate at which molecular networks evolve is an important question in evolutionary biology. Previous empirical work has focused on interactomes from model organisms to calculate rewiring rates, but this is limited by the relatively small number of species and sparse nature of network data across species. We present a proxy for variation in network topology: variation in drug-drug interactions (DDIs), obtained by studying drug combinations (DCs) across taxa. Here, we propose the rate at which DDIs change across species as an estimate of the rate at which the underlying molecular network changes as species diverge. We computed the evolutionary rat

SUBMITTER: Gil-Gomez A 

PROVIDER: S-EPMC11136681 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature