Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study.

ABSTRACT: It remains unclear whether the association between metformin and osteoporosis (OP) risk is causal. This two-sample Mendelian randomization (MR) study suggests a causal relationship between metformin treatment and a decrease in OP and fracture incidence, as well as an increase in bone mineral density (BMD) in the lumbar spine, femoral neck, and heel. Nonetheless, no significant causal effect is observed on forearm BMD.

Purpose

We utilize a MR approach to investigate the association between metformin treatment and the risk of OP.

Methods

Metformin treatment was selected as exposures. Outcomes included OP; BMD at the forearm (FA), femoral neck (FN), and lumbar spine (LS); estimated heel bone mineral density (eBMD); and fracture. Summary statistics for exposures and outcomes were

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11136748 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature