Rheumatoid arthritis and the risk of chronic kidney diseases: a Mendelian randomization study.

ABSTRACT:

Background

The extra-articular lesions of rheumatoid arthritis (RA) are reported to involve multiple organs and systems throughout the body, including the heart, kidneys, liver, and lungs. This study assessed the potential causal relationship between RA and the risk of chronic kidney diseases (CKDs) using the Mendelian randomization (MR) analysis.

Method

Independent genetic instruments related to RA and CKD or CKD subtypes at the genome-wide significant level were chosen from the publicly shared summary-level data of genome-wide association studies (GWAS). Then, we obtained some single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs), which are associated with RA in individuals of European origin, and had genome-wide statistical significance (p5 × 10^-8

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11137270 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature