Diagnosis and management in Rubinstein-Taybi syndrome: first international consensus statement.

ABSTRACT: Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised by intellectual disability, well-defined facial features, distal limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in either of two genes (CREBBP, EP300) which encode for the proteins CBP and p300, which both have a function in transcription regulation and histone acetylation. As a group of international experts and national support groups dedicated to the syndrome, we realised that marked heterogeneity currently exists in clinical and molecular diagnostic approaches and care practices in various parts of the world. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical d

SUBMITTER: Lacombe D 

PROVIDER: S-EPMC11137475 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature