Association of serum uric acid level with intracranial aneurysms: A Mendelian randomization study.

ABSTRACT:

Objective

Numerous studies have posited the involvement of serum uric acid (SUA) in the pathogenesis and progression of various cardiovascular diseases, particularly aortic aneurysms. However, the casual effect of SUA level on intracranial aneurysms (IAs) was rarely studied. Consequently, we aimed to explore the causal association between SUA and IAs using Mendelian randomization (MR) analysis.

Methods

We conducted a two-sample MR analysis with SUA as the exposure variable and IAs as the outcome variable. Genome-wide association study (GWAS) datasets for SUA were acquired from the Open GWAS catalog, including 389,404 European and 129,405 East Asian individuals. The dataset for IAs was sourced from a meta-analysis of GWASs comprising 317,636 individuals across different ances

SUBMITTER: Ye G 

PROVIDER: S-EPMC11137567 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature