Clinical and prognostic associations of anti-Jo-1 antibody levels in patients with antisynthetase syndrome.

ABSTRACT:

Objective

To investigate the association of serum anti-Jo-1 antibody levels with the disease activity and prognosis in anti-Jo-1-positive patients with antisynthetase syndrome (ASS).

Methods

This study included 115 anti-Jo-1-positive patients with ASS who were admitted to China-Japan Friendship Hospital between 2009 and 2019. Anti-Jo-1 antibody serum levels at initial admission and follow-up were determined by enzyme-linked immunosorbent assay (ELISA). Global and organ disease activity was assessed at baseline and follow-up according to the International Myositis Assessment and Clinical Studies guidelines.

Results

Among enrolled patients, 70 (60.9%) patients initially presented with interstitial lung disease (ILD), and 46 (40%) patients presented with with muscle weak

SUBMITTER: Yang H 

PROVIDER: S-EPMC11137886 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature