Integrating a multimodal lifestyle intervention with medical food in prodromal Alzheimer's disease: the MIND-AD_mini randomized controlled trial.

ABSTRACT:

Background

The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) showed cognitive benefits from a multidomain lifestyle intervention in at-risk older people. The LipiDiDiet trial highlighted benefits of medical food in prodromal Alzheimer's disease (AD). However, the feasibility and impact of multimodal interventions combining lifestyle with medical food in prodromal AD is unclear.

Methods

MIND-AD_mini was a 6-month multinational (Sweden, Finland, Germany, France) proof-of-concept randomized controlled trial (RCT). Participants were 60-85 years old, had prodromal AD (International Working Group-1 criteria), and vascular/lifestyle risk factors. The parallel-group RCT had three arms: multimodal lifestyle intervention (nutrit

SUBMITTER: Thunborg C 

PROVIDER: S-EPMC11138035 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature